Registration Dossier
Registration Dossier
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EC number: 259-766-1 | CAS number: 55699-10-0
Endpoint summary
Administrative data
Description of key information
An oral LD50 of >2000 mg/kg was determined in an acute oral toxicity study (OECD 423, GLP).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an OECD 423 guideline study performed in compliance with GLP, the test substance was administered to six female Sprague-Dawley rats per dose by oral gavage (BASF 2008). Rats were exposed to 300 or 2000 mg/kg bw After an observation period of 14 days surviving animals were necropsied. No mortality was observed in all exposed animals. No significant toxicity signs were observed in the animals receiving the 300 mg/kg dosage. Some toxicity signs were observed during the first 4 hours in rats treated with 2000 mg/kg bw (first piloerection and a reduced motor activity were observed in all animals; these symptoms were then associated to porphyrin deposits around the muzzle and hollow flanks). These signs totally disappeared after two days. No organ or macroscopically visible tissue lesion were found during the post mortem examination. The LD50 was determined to be above 2000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
One acute oral toxicity study is available. This study is adequate for covering this endpoint.
Justification for classification or non-classification
Based on oral LD50 of >2000 mg/kg bw classification for acute oral toxicity is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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