2-Propenenitrile, reaction products with ethylenediamine, hydrogenated

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment. For read across justification please refer to IUCLID chapter 13.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

Method: other: BASF-Test

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-(2-aminoethyl)-1,3-propanediamine

EC Number:

236-882-0

EC Name:

N-(2-aminoethyl)-1,3-propanediamine

Cas Number:

13531-52-7

Molecular formula:

C5H15N3

IUPAC Name:

N1-(2-Aminoethyl)-1,3-propanediamine

Details on test material:

- Name of test material (as cited in study report): N.Mono(aminopropyl)-1,2-diaminoaethan (N-3-Amin)
- Analytical purity: 98 %

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 3.42 kg; male: 2.75 kg

Test system

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 ml

Duration of treatment / exposure:

20 h

Observation period:

2 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2.5 x 2.5 cm

Results and discussion

In vivo

Results

Irritation parameter:

other: necrosis in all 2 animals after 1 min, 5 min, 15 min or 20 hours treatment

Basis:

mean

Time point:

other: 24 h

Reversibility:

not reversible

Remarks on result:

other: Both animals died 2 days after exposure

Irritant / corrosive response data:

Based on the necrosis observed 24 hours after 1 min, 5 min, 15 min or 20 min treatment, the test substance is corrosive to the rabbit skin and should be classified according to the EU (R35) and to GHS (Cat 1A)

Other effects:

All 2 animals died within 2 days

Any other information on results incl. tables

Both animals died 2 days after exposure. Based on tcorrosive effects, the substance has to be judged as corrosive to skin.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Cat 1A Criteria used for interpretation of results: OECD GHS

Conclusions:

Classification: corrosive (causes burns)