Registration Dossier
Registration Dossier
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EC number: 201-857-5 | CAS number: 88-75-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- exposure times are 5 and 15 min and 20 hours
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): o- nitrophenol
- Physical state: solid
no further detail provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other:
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): 80% aqueous suspension - Duration of treatment / exposure:
- 1, 5 and 15 min, 20 hours
- Observation period:
- 24 hours and 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back and ear
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol
- Time after start of exposure: 1, 5, 15 min or 20 hour, respecitvely
SCORING SYSTEM: Draize (re-evaluated according to the scoring system of Draize, as recommended by the actual guideline requirements.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: after 5 min exposure of the back
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 15 min exposure of the back
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: after 15 min exposure of the back
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: after 20 hours exposure of the back
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20 hour exposure of the back
- Other effects:
- After 20 hour exposure a scaling is seen after 8 days.
After all exposure times yellow substance leftovers are seen after 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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