Registration Dossier
Registration Dossier
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EC number: 908-552-2 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication that meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Preliminary investigations into the use of a human bronchial cell line (16HBE14o-) to screen for respiratory toxins in vitro
- Author:
- Westmoreland C, Walker T, Matthews J, Murdock J
- Year:
- 1 999
- Bibliographic source:
- Toxicology in vitro, 13, 761-764
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium carbonate
- EC Number:
- 207-838-8
- EC Name:
- Sodium carbonate
- Cas Number:
- 497-19-8
- Molecular formula:
- CH2O3.2Na
- IUPAC Name:
- disodium carbonate
- Details on test material:
- SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.
ANY OTHER INFORMATION: Not reported
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: Human bronchiel cell line (16HBE14o-)
Results and discussion
Any other information on results incl. tables
RS-Freetext:
-TER measurements: Time and concentration dependent decrease
in TER. Also a marked increase in pH of treatment solutions
> 500 microg./ml. However, a similar decrease in TER was
seen when the pH was adjusted to neutral pH using 1 M
hydrochloric acid. Some recovery of TER by 24 hr.
-Cytotoxicity: MTT and NRU measurements showed toxicity,
IC50s being 4770 and 3840 microg./ml resp.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
