Registration Dossier
Registration Dossier
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EC number: 203-764-5 | CAS number: 110-40-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020-06-30 to 2020-07-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl sebacate
- EC Number:
- 203-764-5
- EC Name:
- Diethyl sebacate
- Cas Number:
- 110-40-7
- Molecular formula:
- C14H26O4
- IUPAC Name:
- diethyl sebacate
- Details on test material:
- Batch no 1727003
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Since the substance is insoluble in water, Water Accommodated Fractions (WAFs) were prepared at each concentration tested.
WAFs were prepared at concentrations of 1, 10, and 100 mg/L in loading rate to observe the acute ecotoxic impacts at these levels corresponding to the thresholds of the CLP regulation (1272/2008/EC).
The suspensions were weighed and transferred to a volume of mineral medium and then extracted by orbital agitation for 24 hours followed by filtration at 0.45 μm.
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 22.4 - 23.8
- pH:
- 7.9 - 8.3
- Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 1 - < 10 mg/L
- Nominal / measured:
- nominal
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on an experimental study performed according to the OECD TG 201, the substance exhibits an EL50 between 1 and 10 mg/L (loading rate).
- Executive summary:
Based on an experimental study performed according to the OECD TG 201, the substance exhibits an EL50 between 1 and 10 mg/L (loading rate).
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