Registration Dossier
Registration Dossier
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EC number: 291-907-2 | CAS number: 90506-45-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Study was conducted according to Regulation (EC) No 440/2008: test method C. 1 and OECD guideline 203
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
In a 96-h acute toxicity study, Danio rerio were exposed to the read-across substance 1-Octadecanol, phosphate, potassium salt at concentrations of 0 and 100.0 mg/L nominal (WAF of 100 mg/L) under static conditions.
The LC50 was determined to be > 100 mg/L 1-Octadecanol, phosphate, potassium salt
(WAF based on nominal concentration).
The NOEC was determined to be ≥ 100 mg/L 1-Octadecanol, phosphate, potassium salt
(WAF based on nominal concentration).
Justification for read-across:
The main compounds of Phosphoric acid, C16-18-alkyl esters, potassium salts and 1-Octadecanol, phosphate, potassium salt are the mono and di-phosphoric esters.
The typical proportion of mono- to di-ester is 35 % to 50 % for both substances, respectively.
The only difference between the substances is varying chain lengths of the alkyl substituents, C16 and C18 or only C18.
Both substances are surfactants and have a polar “head” (the negatively charged phosphoric acid group) and a relatively inert hydrophobic “tail” (the long alkyl substituents).
The chemical behavior of both alkyl esters is expected to be very similar. The difference chain length of the alkyl substituent (C16 and C18 or only C18) is considered not relevant for the toxicological profile of the substances. This is proven by the close similarity of physico-chemical properties and the similar toxicological profile of the substances.
In conclusion read-across for toxicological and eco-toxicological endpoints is considered valid without restrictions.
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