Registration Dossier
Registration Dossier
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EC number: 436-690-9 | CAS number: 220727-26-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h) = 320 mg/L for activated sludge microorganisms (OECD 209)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 320 mg/L
Additional information
A GLP study according to OECD 209 was performed using activated sludge from a domestic wastewater treatment plant to evaluate the effects of Y-15099 (CAS 220727-26-4) to activated sludge microorganisms (Grützner, 2001). The final nominal test item concentrations tested were 10, 32, 100, 320 and 1000 mg/L. After three hours the inhibition of the respiration rate was recorded. Up to and including the nominal concentration of 320 mg/L the test substance had no inhibitory effects on the respiration rate of microorganisms. An increase in respiration rate was observed at nominal concentrations of 32, 100 and 320 mg/L.
At the highest concentration of 1000 mg/L the inhibitory effect increased to 23%. This resulted in a NOEC of 320 and a LOEC of 1000 mg/L. Additionally, the toxicity control from the biodegradation study according to OECD 301F showed no inhibitory effects on biodegradation at a nominal concentration of 100 mg/L (Grützner, 2001). Hence, it can be assumed that no inhibition of degradation in sewage treatment plants is anticipated.
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