Registration Dossier
Registration Dossier
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EC number: 449-980-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for the Testing of Chemicals No.423 "Acute Oral Toxicity - Acute Toxic Class Method" (adopted 17 December 2001).
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: rat, Sprague-Dawley CD.
Administration / exposure
- Vehicle:
- other: dimethyl sulphoxide (DMSO).
Results and discussion
Effect levels
- Sex:
- male/female
- Mortality:
- Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3 - Clinical signs:
- Signs of toxicity related to dose levels:
Signs of systemic toxicity noted in animals treated with
2000 mg/kg were hunched posture, lethargy and ataxia.
No signs of systemic toxicity were noted in animals treated
with 300 mg/kg.
The surviving animals showed expected gains in bodyweight
over the study period. - Gross pathology:
- Effects on organs:
Abnormalities noted at necoscopy of animals that died during
the study were abnormally red lungs, dark liver, dark
kidneys and haemorrhage of the gastric mucosa.
No abnormalities were noted at necropsy of animals killed
at the end of the study period.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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