Registration Dossier
Registration Dossier
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EC number: 231-598-3 | CAS number: 7647-14-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study methodology followed was equivalent or similar to standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Details on test material:
- - Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- not specified in the report
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: aqueous solution
- Details on inhalation exposure:
- 42 mg/l adminsitered as an aerosol of a 20% (w/v) aqueous solution
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 42 mg/l adminsitered as an aerosol of a 20% (w/v) aqueous solution
- No. of animals per sex per dose:
- 6 male rats
- Control animals:
- not specified
- Details on study design:
- not specified in the report
- Statistics:
- not specified in the report
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 42 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical signs of toxicity observed
- Body weight:
- not specified in the report
- Gross pathology:
- no significant findings noted at necropsy
- Other findings:
- not applicable
Any other information on results incl. tables
not applicable
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the results of the study, the LC50 of sodium chloride administered as an aerosol of a 20% aqueous solution to male rats was greater than 42 mg/l and hence not classified.
- Executive summary:
An acute inhalation toxicity study was conducted at a dose of 42 mg/l administered as an aerosol of a 20% aqueous solution to male rats and the results of the study indicated that the LC50 of sodium chloride was greater than 42 mg/l and hence not classified.
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