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Current Testing Proposals

Current Testing Proposals

Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below or the Previous Testing Proposals table. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Showing 25 results.
Name EC Number CAS Number Deadline for submitting information Hazard endpoint for which vertebrate testing was proposed Link to the format for submitting information View dossier  
1,1'-dithiobis[hexahydro-2H-azepin-2-one] 245-910-0 23847-08-7 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 14/09/2015 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
1,1,1,3,5,5,5-heptamethyltrisiloxane 217-496-1 1873-88-7
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.
Link
1,1,3,3-tetramethyl-1,3-divinyldisiloxane 220-099-6 2627-95-4
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] 601-409-2 116020-44-1
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
A mixture of: cis-tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-tetrahydro-2-isobutyl-4-methylpyran-4-ol 405-040-6 63500-71-0 10/08/2015 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments Link
Aluminum, benzoate C16-18-fatty acids complexes 303-385-6 94166-87-7 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
butan-2-one O,O',O''-(vinylsilylidyne)trioxime 218-747-8 2224-33-1 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9).
Give Comments Link
dichloro(diphenyl)silane 201-251-0 80-10-4
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9)
Sub-chronic toxicity (90-day): oral
Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9)
Link
dimethoxydiphenylsilane 229-929-1 6843-66-9
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
dodecamethylpentasiloxane 205-492-2 141-63-9 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Decamethyltetrasiloxane (EC 205-491-7).
Give Comments Link
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine 245-642-4 23410-40-4
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
Sub-chronic toxicity (90-day): oral
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
Link
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine 221-336-6 3069-29-2
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
Link
octyltrichlorosilane 226-112-1 5283-66-9 10/08/2015 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) Give Comments Link
potassium 4-isopropylbenzenesulphonate 629-764-9 164524-02-1 10/08/2015 Reproductive toxicity (extended one-generation reproductive toxicity study) Give Comments Link
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane 608-489-8 30499-70-8
10/08/2015
10/08/2015
10/08/2015
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Reaction mass of 6-Amino-5-(4-substituted-sulfophenylazo)-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt and 6-Amino-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-5-[sulfo- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt 445-040-3 -
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Reaction mass of [[(2-hydroxyethyl)imino]dimethylene]bisphosphonic acid, sodium salt and 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane, sodium salt 939-513-8 -
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
Sub-chronic toxicity (90-day): oral
Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
Link
Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid 939-201-1 - 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
Sodium N-lauroylsarcosinate 205-281-5 137-16-6 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity) Give Comments Link
trichloro(hexadecyl)silane 227-575-2 5894-60-0
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
Sub-chronic toxicity (90-day): oral
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
Link
triethoxy(phenyl)silane 212-305-8 780-69-8 10/08/2015 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1)
Give Comments Link
trimethoxy(2,4,4-trimethylpentyl)silane 251-995-5 34396-03-7 10/08/2015 Sub-chronic toxicity (90-day): oral
Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) "
Give Comments Link
Urea, N-octyl-N'-[4-[[4-[[(octylamino)carbonyl]amino]phenyl]methyl]phenyl]-Urea, N-[4-[[4[(octadecylamino)carbonyl]amino]phenyl]methyl]phenyl]-N’-octyl 445-760-8 -
14/09/2015
14/09/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Ureidopropyltrialkoxysilane 449-160-7 116912-64-2
10/08/2015
10/08/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Link
Showing 25 results.


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