Current Testing Proposals

Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

 

Showing 15 results.
Substance Name EC Number CAS Number Deadline for submitting information Hazard endpoint for which vertebrate testing was proposed View dossier Link to the format for submitting information  
(no public substance name available) 916-916-7
26/01/2015
Reproductive toxicity (pre-natal developmental toxicity)
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane 241-867-7 17928-28-8
26/01/2015
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8)
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) 235-935-5 13052-09-0
26/01/2015
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates
3,5-diamino-4-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]benzoic acid sodium salt 480-890-9 906532-68-1
02/01/2015
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant
3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, reaction products with 2-butanone oxime 500-287-7 103170-26-9
26/01/2015
Sub-chronic toxicity (90 day): inhalation
chlorodimethylvinylsilane 217-007-1 1719-58-0
26/01/2015
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethylsilanol (CAS 1066-40-6)
Esterification products of 4,4'-isopropylidenediphenol, ethoxylated and prop-2-enoic acid. 613-584-2 64401-02-1
02/01/2015
Reproductive toxicity (pre-natal developmental toxicity)
Hexamethylene diisocyanate, oligomerisation product, blocked with 3,5-dimethyl-1H-pyrazole 605-318-9 163206-31-3
26/01/2015
Sub-chronic toxicity (90 day): inhalation
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] 258-981-8 54112-23-1
26/01/2015
26/01/2015
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide 419-710-0
26/01/2015
26/01/2015
26/01/2015
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine 231-701-1 7691-02-3
26/01/2015
26/01/2015
Sub-chronic toxicity (90 day): inhalation “|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”
Reproductive toxicity (pre-natal developmental toxicity) “|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9
02/01/2015
02/01/2015
Reproductive toxicity (pre-natal developmental toxicity)
Genetic toxicity in vivo
Reaction mass of Amines, coco alkyl and β-Alanine, N-(2-carboxyethyl)-, N-coco alkyl derivs. and β-Alanine, N-coco alkyl derivs. 915-790-0
26/01/2015
Sub-chronic toxicity (90-day): oral
Reaction mass of ethoxylated (≥ 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate 939-702-5
26/01/2015
26/01/2015
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Ethoxylated bisphenol A diacrylate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Ethoxylated bisphenol A diacrylate
Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane 618-939-5 933999-84-9
02/01/2015
02/01/2015
02/01/2015
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Showing 15 results.


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