Current Testing Proposals

Here you can find the substances and hazard endpoints for which ECHA is currently inviting third parties to submit scientifically valid information and studies.

Please also note the following:

 

The link under 'View dossier'

The link under 'View dossier' to the registered substances website allows easy access to the aggregated dossiers containing further details of the testing proposed including the test method (e.g. if an extended one-generation reproduction toxicity study has been proposed instead of a two-generation study). Related information on the substance subject to the testing proposal can also be seen through this link to the aggregated data per joint registration for a substance, which has been obtained from all registration dossiers that are part of that joint registration. If the related dossier has not yet been disseminated or the substance identity is confidential, such a link cannot be given.

The Total Tonnage Band published does not necessarily reflect the registered tonnage band(s) and associated information requirement obligations. For the 'Total Tonnage Band' of the disseminated dossier, compiled data is calculated from the non-confidential quantities of a substance manufactured and/or imported by all registrants, excluding any quantity directly used as an intermediate to produce a different chemical.  

 

Specific grounds for the testing proposal

In some cases, the registrant may propose testing under Annex IX and X of the REACH Regulation even if the registration tonnage band is lower than the tonnage band of the REACH Annex for which the test is proposed. Such specific testing proposals may be triggered by a concern identified from previous study results and their assessment in the chemical safety report (e.g. based on Annex I.0.5 or the second column of Annex VIII section 8.7.1). This is indicated with a note after each relevant endpoint showing that the testing proposal is based on a concern identified by the registrant.  

 

Read-across/category approach proposed

The registrant may have proposed to apply a read-across/category approach for one or more of the testing proposals based on adaptation according to Annex XI.1.5 of the REACH Regulation. This is indicated for the relevant testing proposal endpoint(s) with a note that testing is proposed for another substance than the registered substance, giving the proposed test substance name and, where available, the EC or CAS number.

 

Showing 1 - 20 of 50 results.
of 3
Substance Name EC Number CAS Number Deadline for submitting information Hazard endpoint for which vertebrate testing was proposed View dossier Link to the format for submitting information  
(chloromethyl)triethoxysilane 239-311-3 15267-95-5
01/12/2014
Genetic toxicity in vivo
(no public substance name available) 434-430-9
01/12/2014
01/12/2014
01/12/2014
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] 244-617-5 21850-44-2
03/11/2014
03/11/2014
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
1,3-diphenylpropane-1,3-dione 204-398-9 120-46-7
03/11/2014
03/11/2014
03/11/2014
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
1,4-diisopropylbenzene 202-826-9 100-18-5
03/11/2014
03/11/2014
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with CAS no. 99-62-7
Sub-chronic toxicity (90-day): oral || Note: testing proposed with CAS no. 99-62-7
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts 939-457-4
03/11/2014
03/11/2014
03/11/2014
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts 939-455-3
03/11/2014
03/11/2014
03/11/2014
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): oral
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) 202-319-2 94-28-0
03/11/2014
Reproductive toxicity (two-generation reproductive toxicity)
2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt 286-344-4 85209-91-2
01/12/2014
01/12/2014
01/12/2014
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
2-amino-2-ethylpropanediol 204-101-2 115-70-8
03/11/2014
03/11/2014
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-amino-1,3-propanediol
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-amino-1,3-propanediol
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated 614-503-3 68441-62-3
03/11/2014
03/11/2014
Reproductive toxicity (two-generation reproductive toxicity)
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed on rabbit.
2-Oxepanone, polymer with 1,6-hexanediol 609-271-5 36609-29-7
01/12/2014
01/12/2014
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol
2-Propyn-1-ol, compd. with methyloxirane 609-530-2 38172-91-7
01/12/2014
Sub-chronic toxicity (90-day): oral
3,3-bis[(dimethylvinylsilyl)oxy]-1,1,5,5-tetramethyl-1,5-divinyltrisiloxane 262-061-1 60111-54-8
01/12/2014
01/12/2014
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
3-(triethoxysilyl)propanethiol 238-883-1 14814-09-6
01/12/2014
01/12/2014
01/12/2014
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
3-methoxy-3-methylbutan-1-ol 260-252-4 56539-66-3
03/11/2014
Sub-chronic toxicity (90-day): oral
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) 407-560-9 107934-68-9
01/12/2014
Bioaccumulation aquatic / sediment || Note: Testing proposal is based on concern identified by the registrant.
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole 500-181-0 68002-42-6
03/11/2014
03/11/2014
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
4-methylthiosemicarbazide 229-563-2 6610-29-3
03/11/2014
03/11/2014
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
bismuth citrate 212-390-1 813-93-4
03/11/2014
03/11/2014
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4)
Showing 1 - 20 of 50 results.
of 3


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