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EC number: 234-842-7
CAS number: 12036-22-5
Reported statistics and error estimates
Estimates of the EC50 concentration values
and their 95 % confidence limits for immobilisation were calculated
using the probit method and trimmed Spearman-Karber method. When the p
value for goodness of fit was > 0.05 and there was no other evidence of
questionable convergence, the probit method was selected for reporting.
When this criterion was not met, the trimmed Spearman-Karber
method was selected for reporting.
No long-term toxicity to aquatc invertebrates of sufficient
quality are available for tungsten dioxide (target substance).
However, long-term toxicity to aquatic invertebrates data are
available for sodium tungstate (source substance), which will be
used for read-across. Due to lower water solubility and lower
toxicity for the target substance compared to the source
substance, the resulting read-across from the source substance to
the target substance is appropriate as a conservative estimate of
potential toxicity for this endpoint. In addition, read-across is
appropriate because the classification and labelling is more
protective for the source substance than the target substance, the
PBT/vPvB profile is the same, and the dose descriptors are, or are
expected to be, lower for the source substance. For more details,
refer to the read-across category approach included in the
Category section of this IUCLID submission and/or as Annex 3 in
Tungsten dioxide was not tested for chronic toxicity to invertebrates
and read-across to sodium tungstate dihydrate was used for this
endpoint. In a reproduction test using Daphnia magna and testing sodium
tungstate dihydrate, the 21-day NOEC for reproduction and growth was
found to be 44.2 mg/L sodium tungstate dihydrate/L or approximately 25.9
mg W/L). Read-across to sodium tungstate is appropriate as sodium
tungstate is of higher solubility under simulated environmental
conditions and has the same classification and PBT profile as tungsten
to similar or lower transformation/dissolution results for tungsten
dioxide (the target substance) than sodium tungstate dihydrate (the
source substance), the resulting toxicity potential would also be
expected to be similar or lower, so read-across is appropriate.
Therefore, the dose descriptors are expected to be sufficiently similar
or higher for the target substance, and read-across to the source
chemical is adequately protective. For more details refer to the
description of the read-across category approach.
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