Registration Dossier
Registration Dossier
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EC number: 229-542-8 | CAS number: 6600-31-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Five male and five female rats received a single dose (1000 or 5000 mg/kg bw) of KAC 4196 as emulsion in cremophor for 24 hours. The animals were observed for mortality, body weight gain and clinical signs through day 7.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane
- EC Number:
- 229-542-8
- EC Name:
- 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane
- Cas Number:
- 6600-31-3
- Molecular formula:
- C19H28O4
- IUPAC Name:
- 3,9-bis(cyclohex-3-en-1-yl)-2,4,8,10-tetraoxaspiro[5.5]undecane
- Details on test material:
- KAC 4196 = 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane, chemical pure product
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: cremophor
- Duration of exposure:
- 24 hours
- Doses:
- 1000 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
None of the animals died. The animals dosed with 1000 mg/kg bw were without findings. Animals which were treated with 5000 mg/kg bw revealed a temporary reduced general condition during an observation period of 7 days.
Applicant's summary and conclusion
- Executive summary:
Five male and five female rats received a single dose (1000 or 5000 mg/kg bw) of KAC 4196 as emulsion in cremophor for 24 hours. The animals were observed for mortality, body weight gain and clinical signs through day 7.
None of the animals died. The animals dosed with 1000 mg/kg bw were without findings. Animals which were treated with 5000 mg/kg bw revealed a temporary reduced general condition during an observation period of 7 days. The LD50 dermal is > 5000 mg/kg bw (m + f rats)
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