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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP and non guideline study, but similar to EU and OECD guideline. The study is sufficient for risk assessment.

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Acute Tox. Data 1, 16-17 (1990)

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.3 (Acute Toxicity (Dermal))
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-(morpholin-4-yl)ethan-1-ol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2 to 3 kg

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: backs of the animals
- % coverage: abot 10% of the total body area
- Type of wrap if used: non-occluding dressing
Duration of exposure:
single exposure for 24 h
Doses:
6300, 8000, 10000 and 160000 mg/kg bw
No. of animals per sex per dose:
5/sex
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Statistics:
no statistics

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality pattern : 1/10 @ 6300 mg/kg bw; 0/10 @ 8000, 10000 and 16000 mg/kg bw
Clinical signs:
no data
Body weight:
no data
Gross pathology:
Necropsy findings (study death) determined that death was not compound related.
Terminal necropsy: No visible lesions were observed.
Other findings:
None

Applicant's summary and conclusion