Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967-11-16 tpo 1967-12-12
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, predated OECD guideline, but scientifically fully acceptable and well documented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF-Test: acute inhalation toxicity with rats exposed to a saturated atmosphere for 8 h.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-(morpholin-4-yl)ethan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: young adult

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Water bath, 200 L air/h, 20°C, saturated atmosphere
The vapors were generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
concentration in air not measured (saturated concentration)
No. of animals per sex per dose:
6 male and 6 female animals
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology, body weight (at start of study)
Statistics:
none

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
other: saturated atmosphere
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: no effects (saturated athomsphere)
Mortality:
no mortality
Clinical signs:
other: eye secretion
Body weight:
no data
Gross pathology:
One aminal: morphological liver damage
Other findings:
none

Applicant's summary and conclusion