Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1998-04-21 to 1998-08-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
flask method
Water solubility:
ca. 624 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
5.9
Key result
Water solubility:
ca. 437 g/L
Conc. based on:
act. ingr.
Temp.:
20 °C
pH:
5.9
Remarks on result:
other: corrected for the purity of 70 % (w/w)

Table: Water solubility of the test substance

Experiment

2

3

Amount of test substance (g)

16.8748

16.8831

Stirring time at 20 °C

3

3

pH at room temperature

5.9

5.9

Water solubility

621.84

625.92

 

Average (experiments 2 to 3): 623.88 g/L

Standard deviation: 2.89 g/L

Relative standard deviation: 0.46 %

Purity-corrected value (70 % w/w): 437 g/L

 

Table: HPLC peak areas from the solubility experiment (dilution factor: 5000) and used standards.

Stirring time at 20 °C (h)

Peak areas (mV*min)

Concentrations (mg/l)

Peak areas (mV*min)

Experiment 2

Experiment 2

Standard B

Standard B

276.659

234.84

261.289

3

275.638

 

260.153

Mean:

276.149

 

260.721

Experiment 2

Experiment 2

Standard B

Standard B

283.246

262.52

296.109

3

280.152

 

294.632

Mean:

281.699

 

295.371

 

Conclusions:
The test substance Reactive Navy FC63805 is very soluble in water with a solubility of 624 g/L (purity-adjusted: 437 g/L) at 20°C and a pH of 5.9.
Executive summary:

The water solubility of the test substance was measured by HPLC in accordance with EU method A.6 and in compliance with GLP. The concentration of the substance was determined by comparison of HPLC peak area with an external standard.

The water solubility was determined to 624 g/l and corrected for the purity of 70 %, resulting in definitive solubility of 437 g/l (RSD: 0.5 %).

Description of key information

A study was performed to determine the water solubility of the test substance Reactive Navy FC63805 following EU method A.6 and in compliance with GLP, using the flask method and HPLC. The test substance is classified as very soluble in water with a solubility of 624 g/L (437 g/L corrected for 70 % purity w/w) at 20°C at a pH of 5.9.

Key value for chemical safety assessment

Water solubility:
437 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test substance Reactive Navy FC63805 was measured by flask method in combination with HPLC and the concentration of the substance was determined by comparison of HPLC peak areas with an external standard.

The water solubility was determined to 624 g/l and corrected for the purity of 70 %, resulting in a definitive solubility of 437 g/l (RSD: 0.5%) at 20°C and a pH of 5.9. The test substance is classified as very soluble in water at the test conditions.