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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2000-01-28 to 2000-02-3
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
GLP compliance:
yes (incl. QA statement)
Key result
Medium:
standard fat
Solubility:
< 0.003 other: mg/100 g fat
Temp.:
37 °C
Remarks on result:
not determinable
Test substance stable:
not determined

Details on result:

Exp. No.

Pre-saturation

Stirring time at 37 °C (h)

Mass ratio

Dissolved test substance/fat (mg/100 g)

Stirring time (h)

Temperature (°C)

1

3.0

30

3

<0.004

2

3.0

30

3

<0.004

3

3.0

30

27

<0.004

4

3.0

30

27

<0.004

5

3.0

50

3

<0.004

6

3.0

50

3

<0.004

7

3.0

50

27

<0.004

8

3.0

50

27

<0.004

Conclusions:
A study was performed according to OECD guideline 116 and in compliance with GLP. The fat solubility of the test substance was less than 0.003 mg in 100 g fat at 37 °C, which is the detection limit of the lowest calibration standard.
Executive summary:

A study was performed to determine the fat solubility of the substance Reactive Navy FC63805. Mixtures of the test substance and fat were stirred for different times (3 or 27 h) and at different temperatures (30, 50 and 37 °C). The saturated liqiud phase was separated from the undissolved test substance by filtration, mixed with hexane and extracted three times with water. The aqueous phases were combined and UV/Vis absorption spectra were recorded between 200 and 800 nm. The test substance showed fat solubility of < 0.003 mg in 100 g fat at 37 °C (i.e. below the detection limit).

Description of key information

A study was performed according to OECD guideline 116 and in compliance with GLP. The fat solubility of the test substance was less than 0.003 mg in 100 g fat at 37°C, i.e. below the detection limit of the lowest calibration standard.

Key value for chemical safety assessment

Solubility in mg/100g standard fat:
0.003
At the temperature of:
37 °C

Additional information

A study was performed to determine the fat solubility of the substance Reactive Navy FC63805. Mixtures of the test substance and fat were stirred for different times (3 or 27 h) and at different temperatures (30, 50 and 37 °C). The saturated liquid phase was separated from the undissolved test substance by filtration, mixed with hexane and extracted three times with water. The aqueous phases were combined and UV/Vis absorption spectra were recorded between 200 and 800 nm. The test substance showed fat solubility of < 0.003 mg in 100 g fat at 37 °C (i.e. below the detection limit).