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Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: does not meet important criteria of today standard method; documentation insufficient for assessment

Data source

Reference
Reference Type:
other: short report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
10 rats, 20 mice, 1 rabbit and 2 guinea pig were exposed to the test substance. 4 ml of a 20% solution of stearylisocyanate in methylene chloride were sprayed twice per day (within 2 hours) in a 400 litre cage. The total exposure time per day was 4 hours. This exposure treatment was repeated on the following 4 days.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octadecyl isocyanate
EC Number:
204-019-7
EC Name:
Octadecyl isocyanate
Cas Number:
112-96-9
Molecular formula:
C19H37NO
IUPAC Name:
1-isocyanatooctadecane

Test animals

Species:
other: rat, mouse, rabbit and guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: methylene chloride
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 consecutive days
Frequency of treatment:
4 hours /day
Doses / concentrations
Remarks:
Doses / Concentrations:

Basis:
other: 4 ml of a 20% solution of stearylisocyanate in methylene chloride were sprayed twice per day (within 2 hours) in a 400 litre cage
No. of animals per sex per dose:
10 rats, 20 mice, 1 rabbit, 2 guinea pig
Control animals:
no

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The rabbit died on treatment day 5. At necropsy an irritation of the trachea and the bronchial tubes was found. In addition, a moderate pulmonary edema was observed in the died rabbit. During the14-day recovery period the remaining test animals recovered very fast and showed a normal condition. At necropsy no macroscopic findings of internal organs were seen.

Applicant's summary and conclusion