Registration Dossier
Registration Dossier
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EC number: 907-349-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
A Buehler test in guinea pigs revealed a skin sensitising potential of octadecyl isocyanate (0.1% induction and challenge conc., >= 70 % incidence of sensitisation) according to a method similar to OECD TG 406 (Fritz 1989).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data available.
Justification for classification or non-classification
Skin sensitisation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Deviating from that a skin sensitising potential in guinea pigs detected in a Buehler test leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1 (H317: May cause an allergic skin reaction).
Respiratory sensitisation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Deviating from that a self classification according to Annex I of Regulation (EC) No 1272/2008 with Category 1 (H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled) is recommended since isocyanates are known as respiratory sensitisers.
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