Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: does not meet important criteria of today standard method; no LD50 derived; documentation insufficient for assessment

Data source

Reference
Reference Type:
other: short report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
4 doses were i.p. tested in rats; no further information
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octadecyl isocyanate
EC Number:
204-019-7
EC Name:
Octadecyl isocyanate
Cas Number:
112-96-9
Molecular formula:
C19H37NO
IUPAC Name:
1-isocyanatooctadecane

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: oil
Details on exposure:
no data
Doses:
250, 500, 1000, 2500 mg/kg
No. of animals per sex per dose:
3 males (250, 500, 1000 mg/kg);
5 males (2500 mg/kg)
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Any other information on results incl. tables

At 500 mg/kg and above accelerated breathing, spastic gait and poor general condition were observed. No animals died up to 1000 mg/kg. After i.p. injection of 2500 mg/kg 2/5 animals died 3 or 8 days after treatment.

Applicant's summary and conclusion