Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 907-349-6 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: does not meet important criteria of today standard method; no LD50 derived; documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other: short report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 doses were i.p. tested in rats; no further information
- GLP compliance:
- no
Test material
- Reference substance name:
- Octadecyl isocyanate
- EC Number:
- 204-019-7
- EC Name:
- Octadecyl isocyanate
- Cas Number:
- 112-96-9
- Molecular formula:
- C19H37NO
- IUPAC Name:
- 1-isocyanatooctadecane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: oil
- Details on exposure:
- no data
- Doses:
- 250, 500, 1000, 2500 mg/kg
- No. of animals per sex per dose:
- 3 males (250, 500, 1000 mg/kg);
5 males (2500 mg/kg) - Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Any other information on results incl. tables
At 500 mg/kg and above accelerated breathing, spastic gait and poor general condition were observed. No animals died up to 1000 mg/kg. After i.p. injection of 2500 mg/kg 2/5 animals died 3 or 8 days after treatment.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
