Registration Dossier
Registration Dossier
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EC number: 907-349-6 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: does not meet important criteria of today standard method; no LD50 derived; documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other: short report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 doses were i.p. tested in rats; no further information
- GLP compliance:
- no
Test material
- Reference substance name:
- Octadecyl isocyanate
- EC Number:
- 204-019-7
- EC Name:
- Octadecyl isocyanate
- Cas Number:
- 112-96-9
- Molecular formula:
- C19H37NO
- IUPAC Name:
- 1-isocyanatooctadecane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: oil
- Details on exposure:
- no data
- Doses:
- 250, 500, 1000, 2500 mg/kg
- No. of animals per sex per dose:
- 3 males (250, 500, 1000 mg/kg);
5 males (2500 mg/kg) - Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Any other information on results incl. tables
At 500 mg/kg and above accelerated breathing, spastic gait and poor general condition were observed. No animals died up to 1000 mg/kg. After i.p. injection of 2500 mg/kg 2/5 animals died 3 or 8 days after treatment.
Applicant's summary and conclusion
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