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EC number: 907-349-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 20 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 626 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity: oral
The acute oral toxicity of octadecyl isocyanate was low with an LD50 value > 20000 mg/kg bw for male and female rats (method similar to OECD TG 401). Single administration of 20000 mg/kg bw was tolerated without mortality. In all animals lethargy was observed 20 minutes post-treatment and ended within 48 hours (Lamb and Matzkanin, 1975).
Acute toxicity: dermal
The acute dermal toxicity of octadecyl isocyanate was low with an LD50 value > 2000 mg/kg bw for male and female rats (method similar to OECD TG 402). Single occlusive administration of 2000 mg/kg bw for 24 hours was tolerated without mortalities. No clinical signs were observed (Lamb and Matzkanin, 1975).
Acute toxicity: inhalation
A study on the acute inhalation toxicity of Stearylisocyanate 65 according to OECD TG 403 was conducted on male and female rats, which were nose-only exposed to liquid aerosol in concentrations of 385, 503, 631, 768, 978 mg/m3 (gravimetric concentrations). The liquid aerosol was generated so that it was respirable to rats. Exposure to concentrations up to 503 mg/m3 were tolerated without mortality whereas concentrations equal to or exceeding 631 mg/m3 resulted in mortality occurring within the first three post-exposure days. In surviving rats the following clinical signs were observed: piloerection, bradypnea, tachypnea, labored and irregular breathing patterns, nostrils with red encrustations, cyanosis, motility reduced, limp, high-legged gait, ungroomed hair-coat, tremor, altered reflexes, hypothermia, and transiently decreased body weights. Clinical signs appeared to be largely related to respiratory effects and subsided almost entirely within the first post-exposure week. Necropsy findings were unremarkable in surviving rats whilst in rats that succumbed evidence of lung edema existed. With regard to the respirability of the aerosol generated internationally recognized recommendations such as of SOT (1992) were fulfilled i.e. the MMAD was approximately 1.5 µm (GSD ~2). In summary, the aerosolized test substance (liquid aerosol) proved to have a moderate acute inhalation toxicity to rats (LC50: 626 mg/m3). Mortality appeared to be causally related to acute lung damage and ensuing lung edema (Pauluhn, 2001).
Justification for classification or non-classification
Acute toxicity: oral
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. According to Annex I of Regulation (EC) No 1272/2008 no classification is required.
Acute toxicity: dermal
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. According to Annex I of Regulation (EC) No 1272/2008 no classification is required.
Acute toxicity: inhalation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Deviating from that a self classification according to Annex I of Regulation (EC) No 1272/2008 with Category 3 (H331: Toxic if inhaled) is recommended based on the results of the available key acute inhalation study.
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