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EC number: 942-381-4 | CAS number: -
- After the intradermal induction well-defined erythema and slight oedema were observed at the injection sites of the control group animals and test group animals at which only Freund's adjuvant/0.9% aqueous NaC1-solutian (1:1) was applied. Injection of the test substance in olive oil DAB 10 or in Freund's adjuvant/0.9% aqueous NaCl-solution (1:1) caused well-defined erythema and slight oedema in the test group animals. The control group animals which were treated with olive oil DAB 10 exhibited well-defined erythema.
- The percutaneous induction was only carried out in the test group because the test substance was applied unchanged and thus no solvent was used. Incrustation, partially open (caused by the intradermal induction) in addition to well-defined erythema and slight oedema could be observed in the animals of the test group.
- The challenge with the unchanged test substance did not cause any skin reactions neither in the test group animals nor in the animals of control group 1.
The substance was tested for its sensitizing effect in an OECD 406 guideline study (in compliance with GLP), on the skin of the guinea pig in the Maximization Test. The intradermal induction with the 5% test substance preparations caused slight to well-defined sings of irritation in the test group animals. After the percutaneous induction with the unchanged test substance the animals of the test group exhibited incrustation, partially open (cause by the intradermal induction) in addition to well-defined erythema and slight edema. No skin effects were observed, in both the test as the control animals, after the challenge (21 days after the intradermal induction). Based on this it was concluded that the test substance does not have a sensitizing effect on the skin of the guinea pig in the Maximization Test.
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