Mesitylene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP, non-guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

As described by Noakes DN and Sanderson DM (1969), A method for determining the dermal toxicity of pesticides. Br. J. Indust. Med., 26, 59-64

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

64742-95-6

Cas Number:

64742-95-6

IUPAC Name:

64742-95-6

Constituent 2

Reference substance name:

Shellsol A

IUPAC Name:

Shellsol A

Details on test material:

- Name of test material (as cited in study report): Shellsol A
- Substance type: hydrocarbon solvent (essentially C9 isomers, particularly trimethylbenzenes)
- Physical state: liquid
- Source: Shell Nederland Raffinarderij B.V. refinery, Pernis, Rotterdam, The Netherlands

Test animals

Species:

rat

Strain:

other: CD (COBS)

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Source: Charles River (UK) Ltd., Manston, Kent, UK
- Age at study initiation:no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS: no data

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

1, 2, 4 mL/kg bw

No. of animals per sex per dose:

2

Control animals:

no

Details on study design:

- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no

Statistics:

not applicable

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 4 mL/kg bw

Remarks on result:

other: no mortalities at 4 mL/kg bw (highest dose tested)

Mortality:

no mortalities

Clinical signs:

other: none

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute dermal LD50 of Shellsol A was greater than 4 mL/kg bw to male and female rats.

Executive summary:

The acute dermal toxicity of Shellsol A was low, the 24 hour LD50 in rats was greater than 4 mL/kg bw to male and female rats (i.e. >2000 mg/kg).