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Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 13 - February 05, 1997
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study has been performed according to OECD and EC guidelines and according to GLP principles.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
according to guideline
other: Directive 92/69/EEC, A.8, HPLC-method
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): Nikkol VC-IP
- Substance type: Colourless to light yellow transparent liquid
- Physical state: Liquid
- Stability under test conditions: stable
- Storage condition of test material: In refrigerator in the dark

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
log Pow
Partition coefficient:
> 6.2
24 °C
Remarks on result:
other: pH unknown
Details on results:
In the HPLC chromatograms of NIKKOL VC-IP, detected at 236 nm and recorded for 11 minutes, no test substance peak was observed. Because
during NOTOX Project 186222 ('Development and validation of an analytical method for NIKKOL VC-IP'), test substance was detected at 236 nm at a comparable concentration level but with a different mobile phase, it was concluded that if test substance had eluted from the column, it had been detected. From the four HPLC chromatograms of 2,4-DDT (i.e. a reference substance with known log Pow of 6.2), the retention time of 2,4-DDT wasdetermined to be 9.4 minutes (mean value). The temperature of the mobile phase was 24°C during the measurements. Comparing the results for
the test substance with the results for 2,4-DDT, it was concluded that the partition coefficient (n-octanol/water) of NIKKOL VC-IP is > 1.6 x 10^6
(log Pow > 6.2).

Applicant's summary and conclusion

The partition coefficient (n-octanol/water) of NIKKOL VC-IP is > 1.6x10^6 (log Pow > 6.2).

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