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EC number: 436-710-6 | CAS number: 756-13-8
Interpretation of results: negative. Validity criteria fulfilled.
Groups of 12 males and 12 females were exposed via inhalation to concentrations of 0, 300, 1000 and 3000 ppm for 6 hours per day during the first 2 weeks for 5 days per week, Thereafter, the animals were exposed until gestation day 19. Male animals were exposed for 4 weeks and then sacrificed. Females were allowed to litter and were sacrificed at or shortly after day 4 of lactation. No treatment related mortalities were seen. Body weights were comparable between the control and exposed animals during premating, gestation and lactation. Food consumption was comparable between the control and exposed animals. All females of the control and exposed groups, except one animal in the low dose group, became pregnant within 4 days. No treatment related effects were seen in any of the reproduction parameters. The number of litters with live born pups was 10, 10, 10 and 12 for the control 300, 1000 and 3000 ppm groups. The number of pups delivered and the number of pups alive on PN 4 were comparable in all groups. Pup weights on PN 1 and PN 4 were comparable in all groups. No treatment related observations were recorded. There were no treatment related differences observed between the control and exposed animals in absolute and relative testes and spididymides weights. No gross changes were noted at necropsy. The NOAEL by inhalation for parental toxicity , fertility, and developmental toxicity was at least 3000 ppm.
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