Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
780 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
25
Modified dose descriptor starting point:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
999 999.999 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
1
Modified dose descriptor starting point:
NOAEC

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
147 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
100
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

The DNEL for the human exposure pattern of Inhalation/Worker/Short-term/Systemic effects = 1286130 mg/m³. The exact value of this DNEL could not be entered higher up.

The following DN(M)ELs were not derived because the following human exposure assessments were evaluated and found not to be relevant:

Dermal DN(M)EL for Acute/short-term exposure - systemic effects

Dermal DN(M)EL for Acute/short-term exposure - local effects

Inhalation DN(M)EL for Acute/short-term exposure - local effects

Dermal DN(M)EL for Long-term exposure - local effects

Inhalation DN(M)EL for Long-term exposure - local effects

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

The following DN(M)ELs were not derived because the following human expsoure patterns were evaluated and found to not be relevant:

Dermal DN(M)EL for Acute/short-term exposure - systemic effects

Inhalation DN(M)EL for Acute/short-term exposure - systemic effects

Oral DN(M)EL for Acute/short-term exposure - systemic effects

Dermal DN(M)EL for Acute/short-term exposure - local effects

Inhalation DN(M)EL for Acute/short-term exposure - local effects

Dermal DN(M)EL for Long-term exposure - systemic effects

Inhalation DN(M)EL for Long-term exposure - systemic effects

Oral DN(M)EL for Long-term exposure - systemic effects

Dermal DN(M)EL for Long-term exposure - local effects

Inhalation DN(M)EL for Long-term exposure - local effects