Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 436-710-6 | CAS number: 756-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.008 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.006 mg/kg sediment dw
- Extrapolation method:
- sensitivity distribution
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.001 mg/kg sediment dw
- Extrapolation method:
- sensitivity distribution
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.006 mg/kg soil dw
- Extrapolation method:
- sensitivity distribution
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Hydrogen Fluoride (CAS#7664-39 -3):
Using available aquatic toxicity data(1), the PNECs were calculated to be 0.9 mg/L for Freshwater and 0.09 mg/L for Marine Water. For the Freshwater PNEC, three long-term tests were available for each of three trophic levels. Daphnia magna was the most sensitive species. A conservative assessment factor of 10 was applied to the mean of two daphnia chronic NOEC results. The Marine Water PNEC was generated using the freshwater chronic data because only two useable marine data points were available. Acute marine data was not more sensitive than chronic freshwater data therefore a conservative assessment factor of 100 was applied to the most sensitive freshwater long-term test result to derive the Marine PNEC. There is no intermittent release of HF to water.
For the STP PNEC, a NOEC was available for activated sludge respiration inhibition. An assessment factor of 10 was applied to the NOEC to derive a PNEC for STP. No test results were available for Sediment or Marine Sediment organisms, therefore the EPM method with the freshwater PNEC and marine water PNEC were used to derive sediment PNECs. Koc was estimated using KOCWIN to be 1.6 and the estimated log Kow was 0.23. The PNECs for Sediment and Marine Sediment were calculated to be 1.02 mg/kg and 0.102 mg/kg, respectively. For Grassland and Agricultural Soil, long-term terrestrial NOECs from three trophic levels were available. Therefore the PNECs for Grassland and Agricultural Soil were based on the most sensitive terrestrial NOEC of microbial nitrate mineralization over 63 days and applying an Assessment Factor of 10. The atmospheric compartment needs to be considered because the most important exposure route of HF for plants is uptake from the atmosphere. The lowest NOEC for 7-months exposure of highly sensitive plant species was used to derive the PNEC for the atmospheric compartment. Because it was derived from a large set of toxicity data for different sensitive and highly sensitive plant species, no application factor is considered necessary. A PNEC atmosphere-plant of 0.0002 mg/m3 was obtained.
Trifluoroacetic acid (CAS#76-05-1):
Using available aquatic toxicity data, the PNECs were calculated to be: 0.0077 mg/L for Freshwater, 0.00077 mg/L for Marine Water, and 1 mg/L for STP. For the Freshwater PNEC, three short-term tests were available for each of three trophic levels. Pseudokirchneriella subcapitata was the most sensitive of all species. A conservative assessment factor of 1000 was applied to result. No Marine Water test data was available. The Marine Water PNEC was generated using the most sensitive freshwater results. An Assessment Factor of 10,000 was applied to the result. There is no intermittent release of TFA to water.
For the STP PNEC, a NOEC of 10 mg/L was available for activated sludge. An Assessment Factor of 10 was applied to the NOEC to derive a PNEC of 1.0 mg/L for STP. For Grassland and Agriculture, a NOEC of 1 mg/kg was available for mung beans. An Assessment Factor of 100 was applied to the NOEC to derive the PNEC of 0.010 mg/kg. No test results were available for Sediment or Marine Sediment. These PNECs were extrapolated using the equilibrium partitioning method (EPM) with the Koc= 0.023 L/kg and the freshwater PNEC = 0.0077 mg/L for freshwater sediment and marine PNEC = 0.00077 mg/L for marine sediment. The PNECs for Sediment and Marine Sediment were calculated to be 0.0060 mg/kg and 0.00060 mg/kg respectively.
Perfluoropropionic acid (CAS#422-64-0):
Using available aquatic toxicity data, the PNECs were calculated to be: 0.0085 mg/L for Freshwater, 0.00085 mg/L for Marine Water, and 1000 mg/L for STP. For the Freshwater PNEC, three short-term tests were available for each of three trophic levels. Pseudokirchneriella subcapitata was the most sensitive of all species. A conservative assessment factor of 1000 was applied to the geometric mean of the two available results. No Marine Water test data was available. The Marine Water PNEC was generated using the most sensitive freshwater results. An Assessment Factor of 10,000 was applied to the geometric mean of the two available results.
There is no intermittent release of PFPA to water.
(1) Data obtained from European Union Risk Assessment Report, CAS No.: 7664-39-3, EINECS No.: 231-634-8, hydrogen fluoride, 1st Priority List Volume: 8; European Commission Joint Research Centre; EUR 19729 EN, 2001.
Conclusion on classification
CAS#756-13-8:
GHS Acute 3/Chronic3
R-phrases: R52/53
For the GHS and DSD classifications of CAS# 756-13-8, the toxicity was calculated by taking the lowest EC50 for PFPA and then calculating the equivalent value in terms of CAS# 756-13-8 (51.9% of the molecule converts to PFPA). This equivalent value was found to be 20 mg/L for CAS# 756-13-8. The evaluation of the BCF of PFPA was utilized for the evaluation of bioconcentration because a BCF test dosing with CAS# 756-13-8 would result in the fish being exposed to PFPA. The same argument applies to biodegradation, although PFPA was not found to readily degrade.
Hydrogen Fluoride (CAS#7664-39-3):
GHS Acute 3; Not chronically toxic by GHS
R-phrases: Not classified as dangerous to the aquatic environment
Trifluoroacetic acid (CAS#76-05-1):
GHS Acute 2; Not chronically toxic by GHS
R-phrases: R52/53
Perfluoropropionic acid (CAS#422-64-0):
GHS Acute 2; Chronic 2
R-phrases: N; R51/53
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1