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Melting point / freezing point

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Description of key information

Key result for CAS # 756-13-8:
Melting/Freezing point: -108 °C (method to determine freezing temperature)
Key result for PFPA (degradation product), CAS# 422-64-0:
Freezing temperature: -1.5 °C, atmospheric pressure not reported (equiv. to OECD 102)

Key value for chemical safety assessment

Additional information

Discussion for CAS# 756-13-8:

The freezing point of CAS# 756-13-8 was assessed in two studies. In the first study, CAS# 756-13-8 held at -79°C in a freezer remained a liquid. In the second study, CAS# 756-13-8 frozen in a liquid nitrogen-pentane slurry melted over a temperature range of -110°C to -106°, for a reported melting point of -108°C. Taken together, the two results indicate that CAS# 756-13-8 freezes at a temperature substantially below any temperature likely to occur in the environment. The determination of the freezing temperature in the first study was based on EEC-Directive 92/69EEC, A.1 and on OECD Guideline no. 102, and was GLP-compliant. It is therefore considered relevant and valid to this endpoint. The second study was not GLP compliant. No method cited in OECD TG102 is considered valid at for freezing temperatures less than -100 °C. However, potential error in the method will not change the conclusion that the test substance freezes at a temperature substantially below any temperature likely to occur in the environment. Therefore, the second study is considered adequate for this endpoint.

Discussion for PFPA (degradation product), CAS# 422-64-0:

The freezing temperature of PFPA was assessed using a method equivalent to OECD method 102, Freezing Point method. The test substance was frozen and temperature was raised in 0.5 °C increments. After each increase the temperature was held for 5 minutes. When nearly melted, the sample temperature was reduced -1.5 °C, at which point the sample refroze. The equilibrium temperature was identified as -1.5 °C. The study was comparable to a guideline study. It is well documented and meets generally accepted scientific principles. The study was not performed under GLP criteria. Therefore the study is reliable with restrictions.