Nickel, 5-[2-(2-hydroxy-3,7-disulfo-1-naphthalenyl)diazenyl]-1H-1,2,4-triazole-3-carboxylate sodium complexes

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental period 20th September 2002 to 5th February 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes

Type of method:

flask method

Remarks:

visual assessment

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

443-510-2

EC Name:

-

Cas Number:

738587-10-5

Molecular formula:

C26H14N10Ni2O18S4 as free acid

IUPAC Name:

dinickel(2+) sodium 3-carboxy-5-[(1E)-2-(7-oxido-2,6-disulfonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide 3-carboxy-5-[(1E)-2-(7-oxido-2-sulfo-6-sulfonatonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide

Results and discussion

Water solubility

Water solubility:

>= 380 000 - <= 430 000 mg/L

Temp.:

20 °C

pH:

>= 7.7 - <= 7.8

Details on results:

Result 38 - 43% w/v (approx.380000 - 430000mg/litre.) at ambient temperature by visual assessment.

No evidence of chemical instability of the test substance was observed. It was very difficult to obtain a precise figure for the water solubility of the test substance due to gel formation.

Any other information on results incl. tables

Preliminary tests

Test  1  2  3  Weight of test substance (g)  2.0925  3.0475 4.0636   Final Volume (ml)  10  10  10  Concentration of substance in test (%w/v)  20.9  30.5  40.6  Visual assessment  Test substance soluble  Test substance soluble  Test substance formed a gel  pH  Not measured  Nt measured  7.8

Further tests were carried out to try to obtain a more precise water solubility. After standing in a constant temperature bath at 25°C ±1°C overnight the tests were allowed to stand at room temperature for several days before a visual assessment of solubility was made.

Test  Weight of test substance (g)  Final Volume (ml)  Concentration of test substance in test (%w/v)  pH  Visual assessment  4  3.5414  10  35.4  Not measured  Soluble  5  3.6365  10  36.4 Not measured   Soluble  6  3.7368  10  37.4  Not measured  Soluble  7  3.8239  10  38.2  7.8  Soluble  8  3.9183  10  39.2  7.8  Formed gel like solution  9  4.2591  10  42.6  7.7  Formed a gel like solution. Small particles present  10  4.3527  10  43.5  Not measured  Formed gel like solution. Small particles present

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
No evidence of chemical instability of the test substance was observed.

Executive summary:

Introduction:

Test was carried out according to EU Method A.6 (Water Solubility)

Results and conclusions:

38 - 43% w/v (approx.380000 - 430000mg/litre.) at ambient temperature by visual assessment.

No evidence of chemical instability of the test substance was observed.