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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 September to 16 October 1991
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study in accordance with internationally recognised guideline

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
other: Directive 84/449/CEE - B3
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: Rat Wistar
Strain:
other: HanIbm: WIST (SPF)
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Polyéthylène-glycol
Duration of exposure:
24 h
Doses:
2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
not required

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Aucun signe de toxicité n'a été observé pendant l'essai.
Gross pathology:
Effects on organs:
Aucune anomalie n'a été observée à l'examen macroscopique
post mortem à la fin de l'étude.
Other findings:
Signs of toxicity (local):
On a noté aucune irritation de la peau pendant l'essai.

Any other information on results incl. tables

No mortality occurred during 15 days of observation.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Toxicity was estimated to be greater than 2000 mg/kg