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EC number: 433-400-2 | CAS number: -
A guinea pig maximisation test was initiated to determine sensitising properties of CA 2342 A (Intermediate of CGA 293343) after challenge exposure by skin contact. The procedure of Magnusson and Kligman for adjuvant tests was followed. Epidermal challenge of 10 male and 10 female guinea pigs (test groups) resulted in no positive responses in all guinea pigs after 24 hours and 48 hours, corresponding to a sensitisation rate of 0%. No irritant skin reactions were recorded for control animals. All animals survived to the scheduled sacrifice. Body weights were unaffected by the treatment.
Based on the sensitization rate of 0%, which is below the threshold of significance (i.e. below 30%) set in Commission Directive 93/21/EEC (18th adaptation to technical progress of Council Directive 67/548/EEC), classification of CA 2342 A (Intermediate of CGA 293343) as to its sensitising properties is not required. This classification also applies to the recent versions of both UN-GHS and EU-GHS (CLP).
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