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EC number: 435-300-4 | CAS number: 82113-65-3
The acute toxicity of bis-trifluoromethane sulfonimide (TFSIH) was investigated following administration of a single oral dose to the rat. The study proceeded in a stepwise manner as follows:
A group of 3 male animals was dosed at a fixed level of 25 mg/kg body weight. No animal died or exhibited significant clinical signs. This was confirmed by dosing a second group of 3 female animals at the same level. None of these animals died or exhibited significant toxicity.
Three male animals were dosed at a higher level of 200 mg/kg. All animals exhibited significant toxicity and died within 24 hours. Three additional males were dosed at an intermediate level of 50 mg/kg. No animal died or exhibited significant clinical signs following dosing. This finding was confirmed by dosing a second group of 3 female animals at the same level. None of these animals died or exhibited significant toxicity.
These results indicate that the test substance has a significant toxic effect in the rat following oral administration of a single dose. The observed toxicity indicates the median lethal dose (LD50) to be greater than 50 mg/kg but less than 200 mg/kg.
In these conditions, TFSIH is toxic by ingestion and classified Acute oral toxicity Category 3 (H301) according to the CLP 1272/2008 criteria.
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