Registration Dossier

Administrative data

First-aid measures

Emergency measure - Inhalation: Remove from exposure. If breathing ceases, give artificial
respiration. Get medical attention immediately.
Emergency measure - Eyes: Rinse opened eye for 15 minutes under running water or with
normal saline solution. Get medical attention immediately.
Emergency measure - Skin: Remove contaminated clothing. Wash exposed area with soap
and water. Get medical attention immediately.
Emergency measure - Ingestion: In case of accidental swallowing, give large amounts of
water. Get medical attention immediately.

Fire-fighting measures

Recommended extinguishing agent: Water, dry chemical or CO2.

Product arising from burning: Under normal conditions of use, this material does not
present a significant fire or explosion hazard, however the
substance is combustible and will burn if involved in a
fire, evolving noxious fumes (eg carbon and nitrogen
oxides). However, there is no experimental evidence to
support the anticipated combustion products.

Product determined by test: N

Protective equipment: Full protective clothing and self-contained breathing
apparatus must be worn.


Fight the fire from a safe distance or protected location.

Accidental release measures

Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.


Wear appropriate personal protective equipment conforming to
the relevant national or international standards, as
mentioned in section 2.3.10.


Avoid dust formation by damping down with water. Absorb
spillages of solutions with a suitable inert material (eg.
sand or soil). Carefully transfer the spillage to waste
containers, or use a sealed industrial vacuum machine
(HEPA). Containers filled with waste material must be
labelled in the same way as the original substance
containers.


Clean the spillage area by dissolving in solvent if
necessary.


Dispose of waste material in accordance with local
regulations and/or according to Schering Plough Good
Environmental Practice (GEP). Incineration is the preferred
disposal method.

Handling and storage

Handling: The substance should be stored, handled and used under
conditions of good industrial hygiene and in conformity with

any local regulations in order to avoid exposure.


Engineering controls are necessary to reduce exposure to the

substance.


When exposure cannot be prevented or adequately controlled
appropriate personal protective equipment should be worn.

Such protective equipment should conform to the appropriate
international or national standards as follows;

Chemical protective gloves to Standard EN374

Chemical protective clothing to Standard EN368

Eye protection to Standard EN166.

Furthermore, when respiratory protective equipment has to be

used, it must be capable of adequately controlling exposure,

be suitable for the purpose, and conform to the appropriate
international or national standards, such as a dust mask
conforming to EN149 FFP1.


These measures should be regarded as a minimum.

Storage: Store in a cool, dry, well ventilated area.


Keep containers tightly closed when not in use.

Packaging of the substance and or preparation: Double polythene lined fibreboard drums or glass
bottles(Laboratory only).

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport code: None
Transport: Avoid crushing the containers. In the event of a spillage,
observe the warning labels on the container.
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Exposure controls / personal protection

Stability and reactivity

Danger other than fire: None known.

Chemical reaction with water: No reactivity with water.

Dust explosion: The results from the dust explosion test for a sample of
1.3% moisture with average particle size distribution of
13µm are as follows:


Kst 62 Bar m/s

st class 1

MIE > 500


This indicates that the substance is a moderate explosion
hazard.

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: There will be no discharge to the environment. Recovery from
minor spillages or accidental discharge is not economically
or technically feasible, and such waste material will be
disposed of by incineration. In principle, it may be
possible to recover larger spillages of uncontaminated
material for subsequent use.

Industry - Possibility of neutralisation: The notification tests have shown that the substance is
acutely harmful if swallowed.

No chemical treatment is practicable to neutralise the
hazardous health properties.


The dust hazard will be minimised by appropriate handling
and storage.

Industry - Possibility of destruction: controlled discharge: Contaminated containers or spillages of solutions mixed with
inert material (eg. sand or soil) should not normally be
disposed of by landfill.

Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning
under controlled conditions at a licensed waste treatment
processor in accordance with local regulations.

Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to
the sewage system or the aqueous environment. However,
adverse effects on sewage treatment systems would be
unlikely.

Industry - Possibility of destruction - other: None.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable.

Public at large - Possibility of destruction: controlled discharge: Not applicable

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.

Public at large - Possibility of destruction - others: Not applicable.