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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
May, 2017. Because of in the NDA 01-04-1385-00 carried out by Germany was not requested to indicate the endpoint study record, considering the data inserted in the course of the assessment to be correct and exhaustive the proper “Adequacy of study” has been selected.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
438-670-5
EC Name:
-
Cas Number:
87199-17-5
Molecular formula:
Hill formula: C7H7BO3 CAS formula: C7H7BO3
IUPAC Name:
(4-formylphenyl)boronic acid
Test material form:
solid

Test animals

Species:
other: rat, Sprague-Dawley

Administration / exposure

Vehicle:
other: 0,5 % Carboxymethylcellulose in dest. Wasser "ENGLISH" 0.5% carboxymethyl cellulose in distilled water

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Während der gesamten Studiendauer ist kein Tier gestorben.
Weder bei den männlichen noch bei den weiblichen Tieren
wurden während der Versuchsdauer Abnormitäten festgestellt.

"ENGLISH"

There were no premature decedents or clinical signs noted
during the study.
Gross pathology:
Effects on organs:
Bei der Sektion der am Ende der Studie getöteten Tiere
wurden keine makroskopisch sichtbaren Effekte festgestellt.

"ENGLISH"

The animals killed at the end of the observation period
showed no macroscopically visible changes.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU