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EC number: 250-480-2
CAS number: 31138-65-5
Signs of dermal irritation noted at the test site of one female
five and six days after dosing were very slight erythema and small
superficial scattered scabs with glossy skin noted at this test site
seven days after dosing. There were no signs of dermal irritation noted
at the test sites of the remaining animals.
Introduction: The study was performed to
assess the acute dermal toxicity of the test item in the Wistar strain
rat. The method was designed to be compatible with the following:
Guidelines for the Testing of Chemicals No. 402 “Acute Dermal Toxicity”
(adopted 24 February 1987)
B3 Acute Toxicity (Dermal) of Commission Regulation (EC) No. 440/2008
Method: A group of ten animals (five
males and five females) was given a single, 24 hour, semi‑occluded
dermal application of the undiluted test item to intact skin at a dose
level of 4041 mg/kg bodyweight (equivalent to 2000 mg active
ingredient/kg bodyweight). Clinical signs and bodyweight development
were monitored during the study. All animals were subjected to gross
Mortality: There were no deaths.
Clinical Observations: Red/brown staining
around the right eye was noted in one male. There were no other signs of
systemic toxicity noted.
Dermal Irritation: Signs of dermal irritation
noted at the test site of one female were very slight erythema, small
superficial scattered scabs and glossy skin. There were no signs of
dermal irritation noted in the remaining animals.
Bodyweight: Animals showed expected gains in
bodyweight over the study period, except for one female which showed
expected gain in bodyweight during the first week but bodyweight loss
during the second week.
Necropsy: No abnormalities were noted at
Conclusion: The acute dermal median lethal
dose (LD50) of the test item in the Wistar strain rat was
found to be greater than 4041 mg/kg bodyweight (equivalent to 2000 mg
active ingredient/kg bodyweight).
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