Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference Type:
other: Body responsible for the test

Materials and methods

Test guideline
according to guideline
other: Annex V
GLP compliance:

Test animals

other: Rat (Charles River)

Administration / exposure

Type of coverage:
other: Purified water
Duration of exposure:
24 h

Results and discussion

Effect levels
Dose descriptor:
Effect level:
> 2 000 mg/kg bw
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: There was no systemic response from any animal during the study.
Gross pathology:
Effects on organs:
No abnormalities were noted in any animal at the macroscopic
examination at study termination on day 15.
Other findings:
Signs of toxicity (local):
Very slight irritation was observed in one female after
bandage removal. In addition very slight to well defined
irritation was seen in one female from day 4. These
reactions had resolved by day 9.

A small area of scab formation was seen in two females from
day 3 and one from day 5 and was also seen on one male from
day 7. These reactions had resolved by day 13.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU