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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 423.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: Rat, Sprague Dawley.

Administration / exposure

Vehicle:
other: Deionised water (suspension).

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 300 mg/kg bw
Mortality:
Female: 300 mg/kg bw; Number of animals: 6; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Clinical signs:
Signs of toxicity related to dose levels:
Mortality: between 5 min and 30 min p.a.


Body weight: There were indications of a reduced body weight
gain of the surviving rats in the second week.

Clinical observations: 300 mg/kg bw: clonic convulsions,
tremor, sedation, piloerection, hunched posture, disturbed
locomotion, apathy; observed from shortly after substance
administration until death or until a maximum of 2 h p.a.

2000 mg/kg bw: tremor, sedation, unconsciousness.
Gross pathology:
Effects on organs:
Maximally filled urinary bladder in one animal at 300 mg/kg.


Systolic heart arrest (2000 mg/kg).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU