Registration Dossier
Registration Dossier
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EC number: 481-730-0 | CAS number: 848301-65-5
Endpoint summary
Administrative data
Description of key information
Additional information
Biotic degradation
The results of a study with the read-across substance Naphtha (petroleum), hydrotreated light showed, that the test item can be considered as readily biodegradable. Due to these results and the high similarity, Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear can be considered to be readily biodegradable. The result was confirmed by QSAR calculation.
Supporting information
A recent review is available which summarises the major metabolic pathways for biodegradation of linear and branched alkanes by microorganisms (Rojo, 2009; see IUCLID section 5.6). It is beyond the scope of this work to review this in depth, but it is relevant and useful for consideration of the primary degradation step for the Naphtha`s constituents. Under aerobic conditions, which are of most significance for conventional understanding of persistence and exposure, oxidation using O2 is understood to be the major breakdown mechanism and various microbial alkane hydroxylase enzymes are of particular significance. In general the initial activation to form a primary alcohol is the first step, followed by oxidation to the aldehyde and subsequently the carboxylic acid. The carboxylic acids undergo β-oxidation. Oxidation may occur at both ends of longer chains, creating a ω-hydroxy fatty acid. Degradation of very long chains and branched structures is a more specialised process but several bacterial strains are known to degrade such structures. Degradation of ring structures is not discussed in this review.
In general terms, degradation can be seen to relate to the carbon range present in test material. This is consistent with water solubility limiting the rate of uptake by microorganisms.
In studies of any multi-constituent test substance, there will be uptake of the more bioavailable constituents first. If homologous series are present, it is possible that micro-organisms will adapt to the general structural types present, but it is inevitable that rates will overall appear to be slower than for pure substances.
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