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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: followed OECD methods and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC, C2
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
414-490-2
EC Name:
-
Cas Number:
154212-59-6
Molecular formula:
C11H9ClN2O5S
IUPAC Name:
4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride

Sampling and analysis

Analytical monitoring:
yes
Details on sampling:
HPLC

Test solutions

Vehicle:
yes
Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: Test substance dissolved in 1% Tween 80/dimethylformamide.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
48 h

Test conditions

Nominal and measured concentrations:
nominal and measured

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
6.5 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.5 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
0.073 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
Comments: All concentrations are expressed in terms of measured concentration. Measured concentrations ranged from 10 - 64% of nominal at 0 hours, 0 - 64% of nominal at 24 hours, 0 - 45% of nominal at 48 hours, 47 - 55% of nominal at 72 hours and 25 - 28% of nominal at 96 hours. Despite the use of a dynamic test design, it was not possible to maintain nominal concentrations at a steady state level.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
EC50 at 48 hrs is 2.5 mg/l under test conditions. Measured concnetrations ranged from 53 - 121% of nominal at 0 hours and 0 - 19% at 48 hours. Nominal concentrations could not be maintained in the study.