Registration Dossier
Registration Dossier
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EC number: 414-490-2 | CAS number: 154212-59-6
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: followed OECD methods and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC, C2
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 414-490-2
- EC Name:
- -
- Cas Number:
- 154212-59-6
- Molecular formula:
- C11H9ClN2O5S
- IUPAC Name:
- 4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- HPLC
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: Test substance dissolved in 1% Tween 80/dimethylformamide.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Nominal and measured concentrations:
- nominal and measured
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.073 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Comments: All concentrations are expressed in terms of measured concentration. Measured concentrations ranged from 10 - 64% of nominal at 0 hours, 0 - 64% of nominal at 24 hours, 0 - 45% of nominal at 48 hours, 47 - 55% of nominal at 72 hours and 25 - 28% of nominal at 96 hours. Despite the use of a dynamic test design, it was not possible to maintain nominal concentrations at a steady state level.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 at 48 hrs is 2.5 mg/l under test conditions. Measured concnetrations ranged from 53 - 121% of nominal at 0 hours and 0 - 19% at 48 hours. Nominal concentrations could not be maintained in the study.
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