Registration Dossier
Registration Dossier
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EC number: 414-490-2 | CAS number: 154212-59-6
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 April - 09 May 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out in accordance with method C7 of commission directive 92/69/EEC and in accordance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 414-490-2
- EC Name:
- -
- Cas Number:
- 154212-59-6
- Molecular formula:
- C11H9ClN2O5S
- IUPAC Name:
- 4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- HPLC method with UV detection at 265nm
Samples taken at T=0, 2.4hrs and 5 days. - Buffers:
- ph 4.00, 7.00 and 9.00
- Details on test conditions:
- performed at 50 C and pH 4.00, 7.00 and 9.00 with a stating conc. of c. 20mcg/ml at pH 7 (representing < 0.01M)
Duration of testopen allclose all
- Duration:
- 2.4 h
- pH:
- 8.95
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.004 g/L
- Duration:
- 5 d
- pH:
- 8.95
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 0.004 g/L
- Number of replicates:
- Two
- Positive controls:
- yes
- Remarks:
- Spiked soln at pH4.
- Negative controls:
- yes
- Remarks:
- Bufferer solns pH4, 7 and 9
Results and discussion
- Preliminary study:
- 32.1% hydrolysis at 50°C after 2.4hrs
- Test performance:
- The pH of the test solls remained constant over the duration of the test.
Any other information on results incl. tables
Recovery of spiked solutions: 105%
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A-87439.1 has been found to undergo significant hydrolysis at pH 4, 7 and 9.
At 25°C the test substance will possess a half-life of between 1 day and 1 year at pH4, and less than 1 day at pH 7 and 9. - Executive summary:
Hydrolysis at 2.4hrs at 50°C was 32.1% at pH 4, 91.8% at pH 7 and 100% at pH 9
Hydrolysis at 5 days at 50°C was 93.9% at pH 4 (after correction for instability)
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