Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.1
Temp.:
35 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
3.4
Remarks on result:
not measured/tested
Remarks:
calculation of the partition coefficient
Conclusions:
The calculation of the partition coefficient yielded:
log Pow test substance: 3.4.

Results of the experimental determination of the partition coefficient with the HPLC method, at pH 7:
The temperature during the procedure was 35 °C.
The equation of the linear regression for the reference substances was:
log (capacity factor) = 0.4902 x log (Pow) – 0.9567.
The results of the individual determinations of the decadic logarithm of the partition coefficient (log Pow) of "SPP100 P7" were 3.07 and 3.14. The mean decadic logarithm of the partition coefficient (log Pow) of "SPP100 P7" is 3.1.

The values of log P derived from the individual measurements fall within a range of ± 0.1 log units.

Description of key information

The calculation of the partition coefficient yielded:

log Pow test substance: 3.4.

Results of the experimental determination of the partition coefficient with the HPLC method, at pH 7:

The temperature during the procedure was 35 °C.

The equation of the linear regression for the reference substances was:

log (capacity factor) = 0.4902 x log (Pow) – 0.9567.

The results of the individual determinations of the decadic logarithm of the partition coefficient (log Pow) of "SPP100 P7" were 3.07 and 3.14. The mean decadic logarithm of the partition coefficient (log Pow) of "SPP100 P7" is 3.1.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.1
at the temperature of:
35 °C

Additional information