Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24h
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: DB4900000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1053,1986
Reference Type:
review article or handbook
Title:
DPIM: AKI250
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials); Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.:1972, 182.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
EC Number:
202-546-7
EC Name:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
Cas Number:
96-93-5
Molecular formula:
C6H6N2O6S
IUPAC Name:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
Details on test material:
- Name of test material: 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
- Molecular formula: C6H6N2O6S
- Molecular weight: 234.19
- Substance type: organic

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg/24H
Duration of treatment / exposure:
24H

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: Mildly irritating

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is found to be slightly irritating to rabbit's skin at 500 mg/24H of concentration.
Executive summary:

3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is found to be slightly irritating to rabbit's skin at 500 mg/24H of concentration.