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EC number: 471-140-1
CAS number: 121240-56-0
The "positive level" of ear swelling which is 2 x 10-2 mm increase, i.e.
about 10% of the control values, has not been reached or exceeded in any
dose group. A significant increase of ear weight compared to vehicle
treated animals was detected in the highest dose group (10 %),
indicating an irritating effect. It has to be clarified that the
"positive levels" mentioned above are exclusively defined for the NMRI
outbred mice used for this study. Such positive limits have to be
calculated for each strain of mice individually. The body weights of the
animals were not affected by any treatment.
Tetrabutylphosphoniumhydrogendifluorid has no sensitizing potential in
mice after dermal application of up to and including a 10 %
concentration. Therefore, the concentration of 10 % turned out to be the
NOEL for the parameters investigated in this study with respect to skin
sensitization. These results indicate that the test substance can be
considered as a non-sensitiser (IMDS = modified LLNA).
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