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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Parent fertility
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : DK6650000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Phenyl-p-benzoquinone
EC Number:
206-654-5
EC Name:
Phenyl-p-benzoquinone
Cas Number:
363-03-1
IUPAC Name:
2-phenyl-1,4-benzoquinone
Details on test material:
- Name of test material (as cited in study report): phenyl-p-benzoquinone
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
subcutaneous
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Details on mating procedure:
female 1 day(s) pre-mating
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
1 day(s)
Control animals:
not specified

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

Toxic Effects : Reproductive - Maternal Effects - ovaries, fallopian tubes

Effect levels (P0)

Dose descriptor:
dose level: TDLo - Lowest published toxic dose
Effect level:
5 mg/kg bw (total dose)
Based on:
test mat.
Sex:
female
Basis for effect level:
other: Toxic Effects : Reproductive - Maternal Effects - ovaries, fallopian tubes

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The toxicity (TDLo - Lowest published toxic dose) of phenyl-p-benzoquinone was tested in female rats by subcutaneous route shows effects as Reproductive - Maternal Effects - ovaries, fallopian tubes; if the dose concentration reaches upto 5 mg/kg bw (total dose).
Executive summary:

The toxicity value for the target substance was not obtained for reproduction end point and so the same have been considered for a read across substance. The toxicity (TDLo - Lowest published toxic dose) of phenyl-p-benzoquinone was tested in female rats by subcutaneous route shows effects as Reproductive - Maternal Effects - ovaries, fallopian tubes; if the dose concentration reaches upto 5 mg/kg bw (total dose).