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EC number: 410-440-9 | CAS number: 164058-20-2
In a dermal sensitisation study (Rhone-Poulenc, 1992) the sensitization potential of the test substance (E)-5[(4 - chlorophenyl)methylene]-2,2 - dimethylcyclopentanon was evaluated in 30 guinea-pigs by intradermal injection und cutaneous application, according to the maximization method of Magnusson and Kligman (Induction 5 % intracutaneous on day 1, Induction 100 % epicutaneous on day 8, Challenge 100 % epicutaneous on day 22) and OECD Guideline 406. Local irritation was induced on day 7, using 0.5 ml of 10 % sodium laurylsulphate in vaseline, applied to the scapular region.
No clinical signs were observed and no deaths occurred throughout the study. After the challenge application of the test substance, no coetaneous
reactions were observed in the animals of the control group. The body weight gain of the treated animals was unaffected by administration of the test substance. The macroscopic examination of' the skin at the challenge application sites revealed on the right flank of 2 treated animals an erythema after 24 and/or 48 hours. No edema was noted. The reactions noted (very slight erythema in one animal and well-defined erythema in one animal after 24 hours, very slight erythema in one animal after 48 hours) were considered to be due to a slight sensitization effect in 2/20 animals. After 48 hours, a dryness of the skin was also noted in 1/10 treated animals.
The test item was not a skin sensitizer in the present study.
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