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EC number: 425-240-7
CAS number: -
Maximum concentration not causing irritating effects in preliminary test: 30 %
Signs of irritation during induction:
Intradermal injection - no erythema at sites injected with test material
Topical application - slight erythema at treatment sites in test
animals, none in controls.
Evidence of sensitisation of each challenge concentration: None
A similar level of mild irritation was apparent at sites challenged with
Alembicol D only in both treated and control animals.
No clinical observations of ill health or toxicity were noted
during the study.Body weight increases were recorded for all animals on
Day 25 in comparison with Day 1.
A skin sensitisation test according to OECD TG 406 (GPMT) was conducted
on 10 male or female guinea pigs receiving each three pairs of
intradermal injections (anterior: FCA emulsion, middle: 3% test
substance in distilled water, posterior: 3% test substance in FCA
emulsion) and a topical application (30% test substance in Alembicol D)
for induction. The challenge treatment was performed using either a 30 %
or a 15% test substance formulation in Alembicol D. Dermal responses to
challenge were assessed 48 and 72 hours after the beginning of the
1/10 animals of the group receiving 30% test substance formulation for
challenge and 2/10 animals of the group receiving 15% test substance
formulation for challenge exhibited skin reactions. Each 1/5 animals of
the control groups receiving 30% or 15% test substance formulation for
challenge showed skin reactions. A similar level of mild irritation was
also apparent at sites challenged with vehicle only in both treated and
control animals. Thus, under the conditions of the test no skin
sensitisation potential was detected.
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