Registration Dossier
Registration Dossier
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EC number: 201-379-7 | CAS number: 81-83-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute toxicity upon intraperitoneal injection with 14-day observation period.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Naphthalene-1,8-dicarboximide
- EC Number:
- 201-379-7
- EC Name:
- Naphthalene-1,8-dicarboximide
- Cas Number:
- 81-83-4
- Molecular formula:
- C12H7NO2
- IUPAC Name:
- 3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione
- Details on test material:
- - Name of test material (as cited in study report): Naphthalimid fest (solid)
- Physical state: solid
- Analytical purity: ca 99.5%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.5% CMC in water
- Details on exposure:
- 14-day observation
- Doses:
- 2150, 3160 and 4600 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 4600 mg/kg bw, one male and one female animal died one day after exposure. During the second week after exposure, another two males died.
At the mid dose group, one male and one female animal died one day after exposure.
At the low dose group, one male died one day after exposure. - Clinical signs:
- yes (bad general state and loss of body weight (partly until the second week after exposure); additionally unspecific symptoms like dyspnea, apathy, staggering, spastic gait
- Body weight:
- affected (in part strong body weight decrease after test substance administration)
- Gross pathology:
- Surviving animals showed no adverse findings upon necropsy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
