Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A reliable Bacterial Reverse Mutation Assay was performed with J-37 according to OECD Guideline 471 in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and Escherichia coli WP2 uvr A (Mi-Young, 2010). The following test concentrations were used:
0, 1.60, 3.20, 6.40, 12.8, 25.8 and 51.2 µg/plate = +S9
0, 62.5, 125, 250, 500, 1000 and 2000 µg/plate = -S9
The vehicle used was DMSO. The mean number of revertant colonies was less than twice compared to the negative control values at all dose levels of the test substance in the absence and presence of metabolic activation, without dose-related increase.
The growth inhibition was evident at 51.2 µg/plate in TA98 and TA100 strains, more than 64.0 µg/plate in TA1535 stains and 128 µg/plate in the TA1537 strain without metabolic activation. The background lawn could not be observed at 800 and 400 µg/plate of WP2uvrA (pKM101) strains without metabolic activation and any strains with metabolic activation at which deposition was not evident.
The deposition of the test substance was evident greater than 400 and 1000 µg/plate in WP2uvrA (Pkm101) strain without metabolic activation and all strains with metabolic activation, respectively. However, the deposition did not interfere with the colony counting.
Based on the results of this study, the test substance did not exhibit any indications of mutagenic potential under the conditions of this study.
Short description of key information:
A key mutagenicity study (Ames test) with J-37 showed no mutagenicity effect in bacteria.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to DSD and CLP classification criteria for mutagenicity, no classification is required for J-37.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
