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EC number: 700-694-1 | CAS number: 1207339-61-4
Compared to vehicle treated animals there were clear increases regarding the weights of the draining lymph nodes in the mid and the high dose group: weight index 1.00 (0 %) / 1.22 (2 %) / 1.79 (10 %) / 1.60 (50 %). The “positive level” of ear swelling has been exceeded in the high dose group: ear swelling day 1 = 17.58 (0 %) / 17.50 (2 %) / 17.42 (10 %) / 17.50 (50 %); day 4 = 18.00 (0 %) / 18.58 (2 %) / 18.50 (10 %) / 23.50 (50 %); Index day 4 = 1.00 (0 %) / 1.03 (2 %) / 1.03 (10 %) / 1.31 (50 %) A significant increase compared to vehicle treated animals regarding ear weights was detected in the low and the high dose group: ear weight day 4 = 12.44 (0 %) / 13.79 (2 %) / 13.35 (10 %) / 15.74 (50 %); Index day 4 = 1.00 (0 %) / 1.11 (2 %) / 1.07 (10 %) / 1.27 (50 %). The body weights of the animals were not affected by any treatment. This study does point to a non-specific (irritant) and a specific immunostimulating (sensitizing) potential of the test item.
A modified LLNA (IMDS) according to OECD TG 429 was conducted on 6 female NMRI mice per dose group with epicutaneously applied test substance concentrations of 0 % (vehicle control), 2 %, 10 % and 50 %. The study does point to a non-specific (irritant) and to a specific immunostimulating (sensitizing) potential of the test item. This applies to NMRI mice, for weight and cell counts of the draining lymph nodes as well as ear swelling and ear weight indices evaluated after application of the formulated test item. Although it is not possible to calculate an exact EC value from the data obtained, it can be assumed that the EC value is in any case below 2 %.
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