Registration Dossier

Administrative data

First-aid measures

Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious.
Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink.
Obtain medical attention.

Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which may be delayed.

Skin Contact:
Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eye Contact:
Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

Fire-fighting measures

Fire and Explosion Hazards

This material is non-combustible.
Dust clouds are potentially highly sensitive to ignition from incendive electrostatic discharges.
Dust clouds are of very low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer observed up to 400 °C. Ignition of a dust cloud produces a strong dust explosion.
High pressure between 8 and 10 bar is produced during a dust explosion.
Suitable Extinguishing Media No special requirements needed. Water is recommended for fires involving packaging.

Special protective equipment and precautions for firefighters:

Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk.
If possible, contain and collect firefighting water for later disposal.

Specific Hazards arising from the Material: Toxic or corrosive thermal decomposition products are expected when this material is exposed to fire.

Accidental release measures

Personal Precautions
Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.

Environmental Precautions Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.

Clean-up Methods Collect and place it in a suitable, properly labelled container for recovery or disposal. Following removal of spillage, wash down spillage area with copious amounts of water only if waste water can be directed to an on-site waste water treatment system.

Decontamination Procedures
No specific decontamination or detoxification procedures have been identified for this material.
Consider use of water, detergent solutions, or other soluble solvents, for clean-up and decontamination operations.
Avoid decontamination with oxidizing agents such as household bleach, which will release hazardous hydrochloric acid vapours.

Handling and storage

General requirements
Avoid dispersion as a dust cloud.
Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion hazards during handling of this material.

Ignition controls:
Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.
Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but have been recorded up to 100 mJ.
Minimise the use of plastics when handling this material.
The maximum surface temperature of enclosures potentially exposed to this material should be the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum temperature of 325 °C.

Protective systems:
Assess operations based upon available dust explosion information to determine the suitability of preventive or protective systems as precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of containment, venting or suppression of dust handling equipment. Where explosion venting is considered the most appropriate method of protection, vent areas should preferably be calculated based on the Kst rather than the St value. If nitrogen purging is considered as the protective system, it must operate with an oxygen level below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-down facility in the event of excessive oxygen being detected.
At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic charge is considered likely to occur even when handled in an earthed (grounded) environment.
At ambient humidity, this material has a long charge relaxation time. Accumulation of electrostatic charge is considered likely to occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge.
At low humidity, this material has a very long charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur even when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material might present a very high risk of producing an electrostatic discharge.

Keep in tightly closed containers or packages away from moisture and away from sources of ignition.
Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately
20 degrees C).

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
Not regulated in transport.
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Marine transport (UN RTDG/IMDG)

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Air transport (UN RTDG/ICAO/IATA)

UN number:
Not regulated in transport.
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Exposure controls / personal protection

Engineering Controls
This material has been assigned to GlaxoSmithKline Occupational Hazard Category 1 with a hygiene guide of >1000 - 5000 mcg/m3. An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.

No special engineering controls are required.

Local exhaust ventilation (LEV) is recommended

Personal Protective Equipment
Eye Protection: Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be sought from your local EHS department.

Respiarity protection:
If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as well as hazards, physical properties and warning properties of substances present. Follow local regulations for respirator use in the workplace.

Other equipment or procedures
Wear appropriate clothing to avoid skin contact. An eye wash station should be available

Stability and reactivity

Conditions to Avoid
Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud

Disposal considerations

Collect for recycling or recovery if possible. The recommended method of disposal is incineration.
Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of material in a licenced commercial chemical incinerator.

Regulatory Requirements

Observe all local and national regulations when disposing of this material.