Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Principles of method if other than guideline:
/
GLP compliance:
yes (incl. certificate)
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Details on test material:
> 99 wt%

Results and discussion

Water solubility
Water solubility:
4.87 mg/L
Temp.:
20 °C
pH:
> 6.7 - < 6.9

Any other information on results incl. tables

1.1.1.   Preliminary test

The content of test substance dissolved in the water sample was 1.80 mg/l in Experiment 1 and

97.2 mg/l without centrifugation and 3.49 mg/l after three consecutive centrifugation steps in Experiment 2.

 

1.1.2.   Main study

The results of the second main study for the samples taken at 24, 48 and 72 hours are given in

Table9.

 

The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was > 15%. Since the analysed concentration increased with time, the stirring period was prolonged. The samples were analyzed without centrifugation since this sample treatment step appeared to influence the analysed concentration.

 

The results for the samples taken at 100, 124 and 148 hours are given inTable9. The 124-hour measurement was significantly higher than the 100- and 148- hour measurements (maximum difference (MD) > 15%) after the prolonged stirring period. Based on this, the water solubility of the test substance was given as the mean value of the 100- and 148-hour measurements.

 

No test substance was detected in the pretreated sample from the blank water mixture.

 

Table9           Water solubility of the test substance

Stirring time

[hours]

Sample treatment step

Analysed concentration
[mg/l]

Mean

[mg/l]

MD

[%]

pH

 

 

 

 

 

 

24

Centrifugation

2.37

2.791

331

6.1

 

 

 

 

 

 

48

Centrifugation

2.72

 

 

6.1

 

 

 

 

 

 

72

Centrifugation

3.29

 

 

6.0

 

 

 

 

 

 

100

Direct sampling

5.02

4.872

6.02

6.7

 

 

 

 

 

 

124

Direct sampling

7.74

 

 

6.7

 

 

 

 

 

 

148

Direct sampling

4.72

 

 

6.9

 

 

 

 

 

 

 

 

 

 

 

 

1           For the 24-, 48- and 72-hour samples after centrifugation.

2           For the 100-, 124- and 148-hour samples after direct sampling.

 

 

1.2.    Conclusion

The slow-stirring flask method was applied for the determination of the water solubility of V125226.

 

The water solubility of the test substanceat 20°C was 4.87 mg/l.

 

The pH of the aqueous samples was 6.7 – 6.9.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)